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•Central nervous
system pathology in WD results from copper deposition in the basal
ganglia.
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•Patients may report
central nervous system signs and symptoms, such as drooling, speech changes,
incoordination, tremor, difficulty with fine motor tasks, and gait
difficulties.
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•Psychiatric
manifestations include compulsive behavior, aggression, depression, impulsive
behavior, and phobias.
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•The patient or
parent often reports deterioration in school or job performance. Intellect is
unchanged.
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