–The product of the WD gene is expressed in renal tissue,
but whether the renal symptoms are primary or secondary to release of copper
from the liver is unknown.
–
–Renal complications tend to be functional changes
unrelated to identifiable histologic findings.
–
–Rarely, patients with WD develop renal stones and
associated symptoms. Renal stones are precipitated by hypercalciuria and poor
urine acidification. Therapy with copper-chelating agents can improve renal
function
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