Current drug therapy for wilsons disease
Common
side effects
Usual
dose
Chelating
Drug
Anemia
, thrombocytopenia , bone
marrrow depression and hepatotoxicity
120
mg/kg/day in six divided
doses
Ammonium
tetrathiomolybdate
Same as
penicillamine
25mg/kg/day
in 3 divided doses
Trientene
Abdominal
discomfort
25-30
mg of elemental zinc 3 times a day
Zinc
Thrombocytopenia,
bone marrow depression, proteinuria, autoimmune conditions,worsening of neurological symptoms
Start
10mg/kg/day increase to 20-30mg/kg/day in 2-3 divided doses
D-penicillamine