"Prepared by : Dr."

 PARTICULARS OF PATIENT

Presented with

History of Present Illness

History of Present Illness..

Past medical history

FAMILY HISTORY

GENERAL EXAMINATION

Abdominal examination

Other systemic examination

INVESTIGATIONS

Investigations contd.

Investigations contd

Investigations contd

"Discussion"

Causes of massive splenomegaly

Discussion (contd)

Further investigations

Kayser-Fleischer ring) Ring with sub capsular brownish opacity.

FINAL DIAGNOSIS

Treatment

WILSON’S DISEASE

"In Wilson disease,"

Demography

Presentation of the disease

Gastrointestinal System

Neuro-psychiatric manifestations

KF rings and WD

Renal disease

Muskuloskeletal system

Cardio vascular disease in WD

Hematological

Skin

Diagnosis

Other  findings

Neuroimaging studies

In a neurological setting, diagnosis of WD is easier, as a
KF ring would be positive in almost all cases and along
with either a low ceruloplasmin or high urinary copper,
would be diagnostic. In liver disease, diagnosis can be
more complex. WD is strongly suggested by any two of
the following – low ceruloplasmin, high urinary copper,
presence of KF rings, and confirmed by a high hepatic
Cu. If a liver biopsy is not possible due to coagulopathy,
but other investigations are suggestive of WD, chelation
therapy can be started immediately. Liver biopsy must
then be done at the earliest opportunity, as hepatic copper may remain elevated despite years of therapy and clin-
ical improvement

Medical care

"Current drug therapy for wilsons..."

Further care

Slide 41

"Outcome in wilson disease"

"A poor prognosis (i.e"