| Chelating
Drug |
| Usual dose |
| Common side
effects |
| D-penicillamine |
|
|
|
|
| Start
10mg/kg/day |
|||
| increase
to 20- |
|||
| 30mg/kg/day
in 2-3 |
|||
| divided doses |
|||
|
|
|
|
| Thrombocytopenia,
bone |
|||
| marrow
depression, |
|||
| proteinuria,
autoimmune |
|||
| conditions,worsening
of |
|||
| neurological
symptoms |
|||
| Zinc |
|
|
|
| 25-30
mg of |
||
| elemental
zinc 3 |
||
| times a day |
||
| Abdominal
discomfort |
| Trientene |
|
|
| 25mg/kg/day
in 3 |
|
| divided doses |
|
| Same as
penicillamine |
|
|
|
| Ammonium |
||
| tetrathiomolybda |
||
| te |
||
|
|
| 120
mg/kg/day in |
|
| six divided
doses |
|
|
|
|
|
| Anemia , |
|||
| thrombocytopenia
, bone |
|||
| marrrow
depression and |
|||
| hepatotoxicity |
|||