Institutional Review Board (IRB) was established in 2004 in the Institute of Medicine under the Research Committee with the objective of doing an ethical review of the proposals submitted by the faculties and the students within the institute. The Institutional Review Board consists of members from various departments within the Institute. The mandate of the IRB is to monitor and review all the research conducted by IOM faculty, students and staff that compiles and analyzes data gathered about human subjects. In addition, the IRB reviews research conducted by parties not affiliated with the Institute, but which uses IOM students, faculty or staff as research subjects. Till date, IRB has given approval to 92 research proposals.

Duties promulgated to institutional review boards include ethics consultation, education, peer review, monitoring of clinical trials, and protection of the safety and welfare of research subjects. Additional roles include initial protocol review, ongoing review, and monitoring of adverse events. Furthermore, institutional review boards maintain the authority to sanction and enforce rules regarding noncompliant investigators by rejecting a proposal or terminating an investigation.

The IRB has been formulated by Dean as follows

Chairperson: Professor Dr. Pushpa Raj Sharma, Head, Department of Paediatrics

Member: Prof. Pradeep Vaidya,  Department of Surgery

Member: Prof. Ritu Prasad Gartoulla, Department of Community Medicine and Family Health

Member: Dr. Ram Kumar Ghimire, Associate Professor  Department of Radiology

Member: Dr. Dinesh Kafle, Lecturer, Department of Orthropedics

Member: Mrs. Jamuna Sayami, Matron, Tribhuvan University Teaching Hospital

Member: Prof. Sarala Joshi, Nursing Campus, Maharajgunj

Member: Prof. Dhanik Lal Bharker, Ayurved Campus

Member: Mrs. Meena Rai, Assistant Administrator, Institute of Medicine

Member-secretary: Professor Dr. Bharat Mani Pokhrel, Head, Department of Microbiology